【摘要】 目的探讨益气活血中药复方固本抑瘤Ⅱ号对小鼠Lewis肺癌的作用及与化疗药物环磷酰胺(CTX)合用的效果。方法60只C57BL/6小鼠随机分为:对照组,CTX化疗组(CTX)(30mg/kgCTX腹腔注射),固本抑瘤Ⅱ号中剂量组(M)35g/(kg.d)灌胃、高剂量组(H)70g/(kg.d)灌胃,固本抑瘤Ⅱ号中剂量加CTX组(M+CTX)、高剂量加CTX组(H+CTX),每组10只。观察固本抑瘤Ⅱ号对Lewis肺癌移植瘤与转移瘤的作用,及与CTX合用的效果。结果固本抑瘤Ⅱ号M组、H组的抑瘤率(IR)分别为23.35%、36.82%,瘤重分别为(2.82±1.56)g、(2.32±1.06)g,与对照组(3.68±1.10)g相比明显缩小,P均<0.05;M+CTX组、H+CTX组抑瘤率分别为71.49%、67.13%,与CTX组的63.35%抑瘤率相比未表现出明显差异;但联合用药效应为0.85<q<1.15,表现为相加作用。M+CTX组、H+CTX组肺转移阳性率分别为80%、70%,与CTX组的70%比较差异不显著;但H+CTX组肺癌转移灶为(2.8±1.7)个,比对照组(5.1±1.4)个明显减少(P<0.05)。结论固本抑瘤Ⅱ号对C57BL/6小鼠Lewis肺癌移植瘤有一定的抑制作用,与CTX合用表现为化疗相加作用,而对转移瘤的抑制作用不明显。更多还原

【Abstract】 Objective To study the effect of Gubenyiliu Formula II (GFII) on Lewis lung carcinoma and its combinative effect with cyclophosphamide (CTX). Method All C57BL/6 mice (n=60) were randomly divided into six groups as follows: the control group, CTX group (intraperitoneal injection of CTX in dose of 30 mg/kg), GFII group in medium dose (M group with GFII in dose of 35 g /(kg·d) orally), GFII group in high dose (H group with GFII in dose of 70 g /(kg·d) orally), group with medium-dose GFII and CTX (M+CTX group) and group with high-dose GFII and CTX (H+CTX group, each n=10). The effect of GFII on Lewis transplantation tumor and metastatic tumor, and combinative effect of GFII with CTX were observed.Result The inhibitory rate (IR) in M group and H group was 23.35% and 36.82% respectively, and the weight of tumor was (2.82±1.56) g and (2.32±1.06) g respectively, which was lower than that in the control group (3.68±1.10) g,P<0.05. The inhibitory rate in M+CTX group and H+CTX group was 71.49% and 67.13% respectively without significant difference compared with that in CTX group (63.35%) but the combinative effect was 0.85<q<1.15 which showed an additive effect. The cancerometastasis rate was 80% in M+CTX group and 70% in H+CTX group with an insignificant difference compared with that of CTX group (70%). The metastases were less in H+CTX group (2.8±1.7) than those in the control group (5.1±1.4),P<0.05.Conclusion GFII has an inhibitory effect on Lewis transplantation tumor in C57BL/6 mice. The combination of GFII and CTX shows an additive chemotherapeutic effect but no obvious inhibitory effect on metastatic tumor.更多还原