【摘要】 目的:探讨多囊卵巢综合征(PCOS)患者体内胰岛素抵抗和瘦素抵抗的情况,进一步研究胰岛素、瘦素、肥胖与PCOS的关系。方法:临床收集30例正常对照者(正常对照组)、30例单纯性肥胖患者(单纯性肥胖组)和41例PCOS患者(PCOS组)的血清标本,分别测定其体质指数(BM I)、瘦素(Leptin)、空腹血糖(FBG)、空腹胰岛素(FINS)、三酰甘油、总胆固醇、高密度脂蛋白和低密度脂蛋白的水平,计算胰岛素抵抗指数(HOMA-IR)。结果:①与正常对照组比较,PCOS组BM I、血清瘦素、FINS、HOMA-IR及低密度脂蛋白水平均显著性升高,高密度脂蛋白水平显著性下降(P<0.05);与单纯性肥胖组相比,PCOS组仅FINS水平显著性升高,BM I显著性降低(P<0.05)。②PCOS组瘦素水平与BM I、FINS、HOMA-IR及三酰甘油水平有关。③正常对照组与PCOS非肥胖组的FINS和HOMA-IR差异无显著性意义(P>0.05),而PCOS肥胖组FINS和HOMA-IR均明显高于单纯性肥胖组(P<0.05);正常对照组与PCOS非肥胖组、单纯性肥胖组与PCOS肥胖组瘦素水平的差异均无显著性意义(P>0.05)。结论:多囊卵巢综合征患者胰岛素水平和瘦素水平明显升高,可能存在胰岛素抵抗和瘦素抵抗;PCOS患者瘦素抵抗与胰岛素抵抗之间可能有相互调节的作用;PCOS患者出现胰岛素抵抗不仅是肥胖的后果,还可能与PCOS有直接的关系;PCOS患者瘦素水平的升高可能是肥胖的伴随表现。更多还原

【Abstract】 Objective:To study the insulin resistance and leptin resistance in women with polycystic ovary syndrome(PCOS).Methods:Body mass index(BMI),serum leptin,fasting blood glucose(FBG),fasting insulin(FINS),serum triglyceride,total cholesterol,high-density lipoprotein,low-density lipoprotein and insulin resistance index(HOMA-IR) were assessed in 30 normal women,30 simple obesity women and 41 PCOS women.Results:①The PCOS patients showed higher levels of BMI,serum leptin,FINS,HOMA-IR and low-density lipoprotein,and lower levels of high-density lipoprotein than that in normal control.Compared to simple obesity women,there only showed higher FINS level and lower BMI in PCOS women.②Serum leptin levels in PCOS patients were concerned with BMI、FINS、HOMA-IR and serum triglyceride levels.③There were no significant difference of the FINS and HOMA-IR between normal women and non obese PCOS women,but the obese PCOS women showed higher levels of FINS and HOMA-IR than that in simple obesity women;the serum leptin levels showed no significant difference between normal women and non-obese PCOS women,simple obesity women and obese PCOS women. Conclusion:PCOS patients may have insulin resistance and leptin resistance;There may have regulative effect between leptin resistance and insulin resistance in PCOS patients;There are direct relationship between insulin resistance and PCOS;The rise of serum leptin level in PCOS women may be the assident manifestation of obesity.更多还原