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胸腺肽对小鼠免疫性肝损伤保护研究

Protective Effects of Thymosin on Immunological Liver Injury of Mice

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【作者】 王鹏秦红霞

【Author】 WANG Peng,QIN Hongxia Nursing College of Zhengzhou University,Zhengzhou 450052,China

【机构】 郑州大学护理学院郑州大学第四附属医院 郑州市450052郑州市450052

【摘要】 目的研究胸腺肽对小鼠免疫性肝损伤的保护作用。方法采用卡介苗联合脂多糖诱导法,建立免疫性肝损伤的小鼠模型,观察胸腺肽对小鼠免疫性肝损伤的保护作用。结果胸腺肽能明显降低免疫性肝炎模型小鼠血清丙氨酸氨基转移酶(ALT)的活性,并能显著减轻肝炎小鼠的肝指数和脾指数(P<0.05)。结论胸腺肽对小鼠免疫性肝损伤有保护作用。

【Abstract】 Objective To study the protective effects of thymosin on immunological liver injury of mice.Methods The protective effects of thymosin were studied on the mouse model of immunological liver injury which was induced by Bacillus Calmette Guerin and Lipopolysaccharide.ResultsThymosin significantly decreased the serum levels of ALT and declined the liver index and spleen index in mouse immunological hepatitis model(P<0.05).Conclusion Thymosin can protect mice from immunological liver injury.

  • 【文献出处】 医药论坛杂志 ,Journal of Medical Forum , 编辑部邮箱 ,2007年01期
  • 【分类号】R575.1
  • 【被引频次】2
  • 【下载频次】105
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