【摘要】 目的观察E-cadherin和β-catenin在人肺癌细胞的表达,探讨E-cadherin/β-catenin复合体在癌细胞淋巴道转移机制中的作用。方法取肺癌手术材料30例,用免疫组化法观察E-cadherin、β-catenin和LYVE-1在癌细胞、血管及淋巴管的表达。结果癌细胞的E-cadherin、β-catenin呈阳性表达;低分化组、有淋巴结转移组E-cadherin表达减弱。淋巴管的LYVE-1阳性表达,E-cadherin阴性表达,β-catenin弱阳性表达。各分子在血管均为阴性表达。结论LYVE-1在淋巴管特异性表达;E-cadherin表达与肿瘤分化程度和有无转移呈负相关;E-cadherin/β-catenin复合物在肿瘤细胞与淋巴管内皮细胞的黏附过程中不起主要作用。更多还原

【Abstract】 Objective To observe the expressions of E-cadherin and β-catenin in lung cancer cells.To explore the effects of the cadherin and catenin interlink complex in lymphatic metastasis of cancer cells.Methods Thirty lung cancer specimens were used in this study.Expressions of E-cadherin,β-catenin,and LYVE-1 on cancer cells,blood vessels,and lymphatic vessels were detected by immunohistochemical method.Results The positive expressions of E-cadherin and β-catenin could be found in the cancer cells.The expressions of E-cadherin declined in poor differentiation group and lymphatic metastasis group.The expression of LYVE-1 on lymphatic vessel was positive.The expression of β-catenin on lymphatic vessels was weak positive.The expression of E-cadherin was negative.The expressions of all moleales in the blood vessels were negative.Conclusion LYVE-1 expresses specifically in the lymphatic vessels.The expression of E-cadherin has negative correlation with cancer differentiation and cancer metastasis.The complex of E-cadherin/β-catenin plays a minor role in the adhesion process of cancer cells and lymphatic endothelial cells.更多还原