【摘要】 目的:探讨雷公藤多甙在大鼠肝移植急性排斥反应中诱导免疫耐受的作用。方法:本实验应用120只肝移植SD大鼠,分为四组:对照组(A组),TII组(B组),CsA组(C组),TII+CsA组(D组)。分别于术后1 d、3 d、5 d、7 d、14 d检测脾脏细胞的CD4+、CD25+、CD8+、CD28+的蛋白表达。结果:三组治疗组的CD4+、CD25+、CD8+的蛋白活性表达均高于对照组,而CD28+的蛋白活性表达却相反。三组治疗组间的CD4+、CD28+的比较,均有显著性差异。结论:雷公藤多甙不但具有免疫抑制作用,而且还能够诱导一定程度的免疫耐受。更多还原

【Abstract】 Objective: To investigate the function of GTW on inducing immune tolerance in rat orthotopic liver transplantation.Methods: One hundred and twenty liver transplantation SD rats were divided into four groups: control group(A),TII group(B),CsA group(C),TII+CsA group(D).Activity of CD4+,CD25+,CD8+,CD28+ in spleen lymphocyte were respectively detected after operation.Results: There were significant difference between the three treated groups,the activity of CD4+,CD25+,CD8+,CD28+ in the three treated groups were higher than in control group.Conclusion: In conclusion,GTW has the function of inducing immune tolerance in some extent except of immune suppression.更多还原