【摘要】 目的探讨河南汉族肺癌患者髓过氧化物酶(MPO)基因启动子区第-463位G→A基因型多态性。方法采用病例-对照研究方法,以聚合酶链反应-限制性片段长度多态技术检测河南省汉族121名正常对照和121例肺癌患者MPO-463G→A基因型多态性,并比较各基因型与肺癌易感性的关系。结果对照组与肺癌组MPO-463G/G、G/A和A/A基因型分布差异无统计学意义(χ2=2.594,P>0.05)。MPO基因-463位点至少携带1个A等位基因的基因型与肺癌发生风险的关联不大,病理分型后各基因型分布差异亦无统计学意义,按吸烟分层后差异仍无统计学意义(P>0.05)。结论未发现河南汉族人群MPO-463G→A基因多态与肺癌发生风险有关联。更多还原

【Abstract】 Aim: To detect the association between MPO polymorphism (463G→A) and the susceptibility of lung cancer in Henan, China. Methods: A case-control study of 121 lung cancer patients and 121 aged-and sex-matched controls was conducted to investigate the polymorphism of MPO gene (463G→A) using PCR-RFLP. The association between the genetic polymorphism and the risk of the cancer was examined by a multivariate analysis.Results: There were no significant differences in the frequencies of genotypes (G/G, G/A, and A/A) between the 2 groups (χ2=2.594, P>0.05). The genotypes (G/A and A/A) of MPO did not elevate the risk of lung cancer even after pathological and smoking stratification. Conclusion: The MPO (463G→A) polymorphism may not involve in lung cancer risk.更多还原