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大肠癌组织中Caveolin-1和EGFR蛋白的表达

Expression of Caveolin-1 and EGFR proteins in colorectal carcinoma tissue

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【作者】 王贵吉； 邢鑫； 倪晨智； 裴迎新； 王相英； 李冰；

【Author】 WANG Guiji1),XING Xin1), NI Chenzhi2),PEI Yingxin3),WANG Xiangying4),LI Bing5)1)Department of Oncology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 4500522)Department of Clinical Medicine,Zhengzhou University,Zhengzhou 450001 3)Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University,Zhengzhou 450001 4)Department of Neurology, People’s Hospital of Linzhou, Linzhou 456550 5)Department of Pathology, College of Basic Medical Sciences,Zhengzhou University, Zhengzhou 450001

【机构】 郑州大学第一附属医院肿瘤科； 郑州大学临床医学系； 郑州大学公共卫生学院营养与食品卫生学教研室； 林州市人民医院神经内科； 郑州大学基础医学院病理学教研室 郑州450052； 郑州450052； 郑州450001； 林州456550；

【摘要】 目的:探讨大肠癌组织中Caveolin-1和EGFR蛋白表达的变化。方法:采用免疫组织化学SP法对外科手术切除的126例大肠癌标本及35例癌旁正常黏膜组织进行Caveolin-1和EGFR蛋白检测。结果:大肠癌组织与癌旁正常黏膜组织中Caveolin-1蛋白阳性表达率分别为30.16%(38/126)和85.71%(30/35),EGFR蛋白阳性表达率分别为61.11%(77/126)和8.57%(3/35),2组间差异均有统计学意义(P<0.01)。大肠癌组织中Caveolin-1和EGFR蛋白的表达均与组织学类型无关(P>0.05),但与分化程度、淋巴结转移以及临床分期有关(P<0.05)。大肠癌组织中Caveolin-1与EGFR蛋白的表达呈负相关(rs=-0.327,P<0.05)。结论:大肠癌的发生发展过程中Caveolin-1和EGFR可能发挥重要作用。

【Abstract】 Aim: To investigate the expression of Caveolin-1 and EGFR proteins in colorectal carcinoma tissue. Methods:The expression of Caveolin-1 and EGFR proteins in 126 cases of colorectal carcinoma tissues,35 para-carcinoma normal mucosa tissues were detected using immunohistochemical method. Results: The positive rates of Caveolin-1 and EGFR in colorectal carcinoma tissue were 30.16%(38/126) and 61.11%(77/126), respectively, which significantly differed from those in normal mucosa tissues 85.17%(30/35) and 8.57%(3/35)(P<0.001 ). The expression levels of the two proteins in colorectal carcinoma tissue were not related to the histopathologic type(P>0.05 ), but correlated with malignant degrees,lymph node metastasis and clinical stages (P<0.05).The expression of Caveolin-1 in colorectal carcinoma tissue was negatively correlated with that of EGFR(P<0.05).Conclusion: The expression levels of Caveolin-1 and EGFR proteins are remarkably related to the progression and tumor metastasis.

【关键词】 Caveolin-1； EGFR； 大肠肿瘤； 癌；
【Key words】 Caveolin-1； EGFR； colorectal carcinoma；
  • 【文献出处】 郑州大学学报(医学版) ,Journal of Zhengzhou University(Medical Sciences) , 编辑部邮箱 ,2007年02期
  • 【分类号】R735.3
  • 【被引频次】6
  • 【下载频次】171
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