【摘要】 目的探讨丙型肝炎患者血清IGF-Ⅱ水平与脂质过氧化物的关系。方法应用放免法测定胰岛素样生长因子Ⅱ(IGF-Ⅱ)水平,化学法测定血浆丙二醛(M DA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)含量,并与35名正常人作对照。结果62例丙型肝炎患者血清IGF-Ⅱ、M DA水平高于对照组(P<0.01),而SOD、GSH-PX水平低于对照组(P<0.01),相关分析显示:丙型肝炎患者血清IGF-Ⅱ水平与M DA呈正相关(r=0.6014,P<0.01)。结论丙型肝炎患者血清IGF-Ⅱ水平的升高与活性氧代谢紊乱有关。更多还原

【Abstract】 Objective To study the relationship between the serum IGF-Ⅱ and lipid peroxidation levels in patients with hepatitis C.Methods Serum IGF-Ⅱ levels were measured with RIA.Plasma MDA,SOD and GSH-PX levels were measured with chemocolorimetry in 62 patients with hepatitis C as well as in 35 controls.Results serum IGF-Ⅱ and MDA levels were significantly higher in the patients than those in the controls(P<0.01).Correlation analysis showed that serum IGF-Ⅱ levels were positively correlated(r=0.6014,P<0.01).Conclusion The higher IGF-Ⅱ levels were closely associated with the lipid peroxidation disturbance in patients with hepatitis C.更多还原