【摘要】 目的:探讨细胞因子在毛细支气管炎中的发病机制。方法:采用双抗体夹心ELISA法测定毛细支气管炎组32例患儿和对照组20例正常儿童血清中IL-4、IL-10、INF-α水平。结果:血清中IL-4、TNF-α水平,毛细支气管炎组显著高于对照组(P<0.05),而IL-10水平毛细支气管炎组显著低于对照组(P<0.05)。血清中IL-4与TNF-α水平之间呈正相关,相关系教r=0.70(P<0.001)。IL-10与IL-4、TNF-α之间无相关关系(P>0.05)。结论:毛细支气管炎患儿血清中IL-4、IL-10、TNF-α水平检测结果与哮喘患儿相近,两者有相似的细胞因子紊乱,细胞因子在毛细支气管炎的发病中起着重要的作用。更多还原

【Abstract】 Objective:To test the levels of IL-4、IL-10、TNF-αin bronchiolitis children and study the relationship between the levels of cell factors and the pathogenesis of bronchiolitis.Methods:The IL-4,IL-10,TNF-αlevels of serum were determined in the bronchiolitis group of 32 cases and the control group of 20 cases by enzyme-linked immunosobent assay(ELISA).Results:The serum levels of the IL-4,TNF-αin the bronchiol- itis group were higher than in the control group(P<0.05).The serum levels of the IL-10 in bronchiolitis group were significantly lower than those of the control group(P<0.05).There were a positive correlation between the levels of IL-4 and TNF-α(P<0.001)and no correlation among the levels of IL-10 and the levels between TNF-αand IL-4(P>0.05).Conclusions:The levels of IL-4,IL-10 and TNF-αin serum of children with bronchiolitis are close to the levels of children with asthma.IL-4、IL-10 and TNF-αplay important roles in the pathogenesis of bronchiolitis.更多还原