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FK506致肝功能异常2例并文献复习

Fk506 caused 2 cases liver damage after kidney transplantation and review of literature

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【作者】 李金庆马潞林赵磊张树栋候小飞王国良罗康平

【Author】 LI Jinqing1),MA Lulin2),ZHAO Lei2),ZHANG Shudong2),HOU Xiaofei2),WANG Guoliang2),LUO Kangping2).1)Department of Urology,the Second Affiliated Hospital of Qingdao University Medical College,Qingdao 266042,Shandong;2)Department of Urology,the Third Hospital of Peking University

【机构】 青岛大学医学院第二附属医院泌尿外科北京大学第三医院泌尿外科北京大学第三医院泌尿外科 青岛266042

【摘要】 目的探讨FK506的肝毒性。方法报告2例肾移植术后应用FK506后,出现转氨酶、胆红素升高。结果1例仅停药后肝功恢复;另1例经停药,保肝治疗后恢复。结论FK506可引起肝脏损害,致转氨酶、胆红素升高,临床应用中注意该项副作用。

【Abstract】 Objective To discuss the drug-induced liver damage by FK506.Methods Clinical data of 2 cases whose alanine aminotransferase(ALT),bilirubin(T-Bil) elevating with oral take FK506 after renal transplantation had been analysed.Results One patient’s hepatic function had returned normal after stopping FK506;the other had returned normal after stopping FK506 and giving liver-protective remedies.Conclusion FK506 may cause liver damage and liver function,so they should be monitored in renal recipients particularly.

【关键词】 FK506肝毒性药物副作用
【Key words】 TacrolimusHepatotocxicityAdverse drug reactions
  • 【文献出处】 临床医学 ,Clinical Medicine , 编辑部邮箱 ,2007年11期
  • 【分类号】R595.3
  • 【被引频次】5
  • 【下载频次】122
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