【摘要】 目的揭示娄底市麻疹IgM抗体的分布特征,探讨该市麻疹相对高发的主要原因。方法采集麻疹疑似病例血清标本用ELISA法检测IgM抗体,全部数据录入MS Excel并用SPSS软件进行分析。结果308份合格血清IgM总阳性率为50.99%,其中按要求完整填写相关信息的219份,标本总阳性率为49.32%;按有明确免疫史、无免疫史和免疫史不详分3组统计,其阳性率分别为38.46%,46.52%和52%,3组阳性率无统计学差异(χ2=1.793 0,P=0.408 0);按采样时间分组统计,出疹后5~10日采样检测阳性率显著高于其他组(χ2=16.967 0,P<0.000 1),对其中麻疹IgM阴性的34份血清做风疹IgM检测,结果仅有4份显示弱阳性。结论麻疹IgM检测采样的最佳时间为出疹后5~10日;免疫空白人群和原始免疫失败为本市麻疹感染发病的主要影响因素。更多还原

【Abstract】 Objective To reveal the distribution characteristics of measles IgM and their implication for measles control in Loudi City.Methods Samples from suspected measles cases were tested by measles IgM-capture ELISA and results were analyzed using MS Excel and SPSS software package.Results Total IgM positive rate was 50.99% for the 308 adequate samples submitted to the city CDC laboratory and that for the 219 samples that met the information requests for detailed analysis was 49.32%.Of the 219 samples,positive rates were 38.46%,46.52% and 52% for the groups of cases:(1) vaccinated,(2) unvaccinated and(3) no documented vaccination,respectively,showing no statistical differences(χ2=1.793 0,P=0.408 0),and positive rates were significantly higher(χ2=16.967 0,P<0.000 1)for the group of samples taken between 5-10 days post rash onset.Only 4 showed weak positive results when 34 measles IgM-negative sera were tested for differential diagnosis from rubella.Conclusions The optimum sampling time for measles IgM detection was 5-10 days post rash onset.Gaps in population immunity and primary failures in immunization were principle factors leading to measles infection and epidemic in Loudi City.更多还原