【摘要】 目的探讨辅助受孕婴儿与自然受孕婴儿的新生情况以及12月龄时的精神运动发育水平有无差异。方法采用配对对照研究方法,将实验组与对照组母亲在年龄、产次、种族、地域、社会阶层、受教育程度等几个方面严格配对后,自母亲孕28周起入组登记并定期随访收集相关资料如婴儿胎龄、出生身长、出生体重、是否需要入住新生儿重症监护室(NICU)、有无出生缺陷等信息,出生后定期随访两组婴儿至12月龄时采用CDCC婴幼儿发育量表行精神运动发育评估。结果辅助受孕组婴儿出生时的身长、体重明显低于自然受孕组(P<0.01),且辅助受孕组婴儿中早产、低出生体重、新生儿期入住NICU等发生率也明显高于对照组(P<0.05),但在剔除两组人群中的双胎妊娠儿,只考虑单胎妊娠儿时,这些差异消失。另外,两组婴儿在12月龄时的智力发育指数(MDI)及运动发育指数(PDI)差异无显著性意义(P>0.05)。结论辅助生殖技术本身对婴儿的生长发育无明显影响,高发的双胎及多胎妊娠是引起辅助受孕儿有更差的新生情况的主要原因。故限制胚胎移植数量,降低双胎、多胎妊娠的发生率将成为保证辅助受孕子代生存质量的当务之急。更多还原

【Abstract】 Objective To compare the neonatal outcome and psychomotor development at 12 months old in infants born after assisted conception with a control group of infants conceived naturally. Methods A matched control study was performed on the neonatal outcome and psychomotor development at 12 months old in infants conceived with use of assisted reproductive technology.The control group was matched according to maternal age,parity,race,area of residence,social class and level of maternal education.The suitable mothers were invited to participate at 28 weeks of gestation and got follow-ups to delivery.The information was collected including the babies’ gestational age,birth weight,length,need for admission to newborn intensive care unit(NICU),and presence of any major malformation,and so on.The children of two groups were followed up to 12 months old and a formal developmental assessment was done with the CDCC Scales of Infant Development.Results The mean birth weight in the assisted conception group were lower than that of the control group,so did the birth length(P<0.01).The incidences ofpreterm birth,low birth weight and admission to NICU were significantly higher in the assisted conception group(P<0.05).But these differences were not significant when the singletons in the two groups were compared.No statistically significant differences were found in the mental development index(MDI)and psychomotor development index(PDI)between study and control groups,as assessed by the CDCC Scales(P>0.05).Conclusion Assisted conception has no obvious influence on the growth of infants.Neonatal outcome after assisted conception is worse than natural conception,mainly due to the large proportion of multifetal gestation after assisted conception.In order to improve neonatal outcome after assisted conception,the number of embryos transferred should be limited to a minimum.更多还原