【摘要】 目的建立注射用盐酸吡硫醇中有关物质的HPLC测定方法。方法采用十八烷基硅烷键合硅胶为填充剂(150 mm×4.6 mm,5μm),以乙腈-水-三乙胺(20∶80∶0.1)(以磷酸调pH至5.0)为流动相,检测波长295 nm。结果在选定的色谱条件下,20 min内注射用盐酸吡硫醇中有关物质与盐酸吡硫醇能较好的分离。结论本法简便,专属性强,适用于注射用盐酸吡硫醇中有关物质的检查。更多还原

【Abstract】 Aim To determine the related substances in pyritinol hydrochloride for injection by HPLC.Methods A hypersil C18 column(150 mm×4.6 mm,5 μm) was used with the mobile phase of acetonitrile-H2O-triethylamine(20∶80∶0.1) at the detection wavelength of 295 nm.Results Under the optimal conditions,a good separation was achieved for pyritinol hydrochloride and its related substances.Conclusion The simple and selective method was successfully used to determine the related substances of pyritinol hydrochloride.更多还原