【摘要】 目的:观察放疗联合化疗及瘤内注射EIB缺失腺病毒(H101)综合治疗鼻咽癌的近期疗效和不良反应。方法:符合入选标准的56例鼻咽癌患者先行化疗和同期颈部肿瘤瘤内注射H101,每天1次,每次1支(5×1011病毒颗粒数/0.5 mL),连续5天,化疗用PF方案(DDP 20mg/m2静滴,d 1~d 5,5-FU 500 mg/m2静滴,d 1~d 5),21天为1疗程。连续2疗程后进行放疗。结果:56例鼻咽癌患者放疗结束时肿瘤消退率为71.4%,好转率为28.6%。放疗后3个月肿瘤消退率为100%。放疗后6个月有2例颈部肿瘤复发。不良反应为注射部位局部疼痛19.6%,非感染性发热41.7%,流感样症状8.9%,白细胞下降42.9%,恶心呕吐33.9%,口腔黏膜损害100%。结论:放疗联合化疗及基因治疗鼻咽癌有明确的近期疗效,毒副反应轻,可望成为鼻咽癌新的综合治疗模式,远期疗效有待进一步观察。更多还原

【Abstract】 Objective:To evaluate the short-term effects and toxicities of radiotherapy combined with chemotherapy and（intratumoral） injection of an EIB gene-deleted adenovirus（H101） in treating patients with nasopharyngeal carcinoma.Methods: A total of 56 patients with nasopharyngeal carcinoma were recruited.They first received chemotherapy based on PF regimen（cisplatin 20 mg/m² ivgtt,qd×5 d;5-fluorouracil 500 mg/m² ivgtt,qd×5 d）.Cervical intratumoral injection of H101(5×10¹¹ viral particle/0.5 mL) was simultaneously administered to patients once daily for 5 consecutive days.Treatment repeated every 3 weeks as 1 cycle.Patients received radiotherapy after they completed 2 cycles of chemotherapy.Results:Among 56 patients,the complete response rate was 71.4% and partial response rate was 28.6% at the end of radiotherapy.The complete response rate was 100% at 3 months after radiotherapy.Recurrence of cervical tumors was found in 2 patients at 6 months after radiotherapy.Main side effects included injection site reaction（19.6%）,fever independent of infection（41.7%）,flu-like symptom（8.9%）,leukopenia（42.9%）,nausea and vomiting（33.9%）,and oral cavity mucosal ulcer（100%）.Conclusions:The combination of radiotherapy and chemotherapy plus H101 injection possessed a distinct efficacy in patients with nasopharyngeal carcinoma with lower toxicities.It may become a new pattern of comprehensive therapy for nasopharyngeal carcinoma.The long-term effect need to be further investigated.更多还原