【摘要】 目的评价585nm脉冲染料激光治疗鲜红斑痣的疗效。方法回顾性分析我科用585nm脉冲染料激光治疗鲜红斑痣患者2317例,总结其治疗次数、皮损性质、是否用同位素等其他治疗与疗效的关系以及不良反应的发生。结果2317例患者分别经过1~13次治疗,治疗间隔2~3个月,中位治疗次数为4·93次,中位治疗能量密度为8·29J/cm2,治疗8次后,总有效率为84%。皮损表现为增生型紫红色斑块或结节者以及在治疗前曾行同位素、冷冻、CO2激光等治疗者,最终治疗的有效率与总体治疗的有效率相比,疗效较差(P<0·05)。2317例患者中,5·2%出现浅表瘢痕,其中94·2%为婴儿和儿童;4·0%出现色素减退;2·5%出现色素增加。结论585nm脉冲染料激光治疗鲜红斑痣疗效好、不良反应发生率低,是治疗血管性疾病首选。更多还原

【Abstract】 Objective To evaluate the efficacy and safty of 585nm flashlamp-pumped pulsed dye lasers(PDL) in the treatment of port-wine stains(PWS). Methods A retrospective review was performed in 2 317 patients with PWS who visited the Dermatology Laser Centre of PUMC Hospital and accepted treatment with 585nm PDL. The corralation between the treatment efficacy and the treatment sessions, lesion types, and usage of other therapies were analyzed. The adverse effects were also observed. Results All the 2 317 patients with PWS received 1-13 consecutive treatments with PDL at 2-3-month intervals. The median number of treatment was 4.93 and the median energy density was 8.29 J/cm~ 2 .The response rate after 8 treatments sessions were 84%. The response rate in patients whose lesions are characterized as purple plaques with proliferation and treated with isotope, CO_ 2 , cryotherapy, and other treatments was significantly lower than the total response rate (P<0.05). Superficial scar, hyperpigmentation, and hypopigmentation were found in 5.2%, 2.5%, and 4.0% of these patients,respectively. Conclusion 585nm PDL is effective and safe in treating PWS.更多还原