【摘要】 目的:研究喹诺酮类化合物脱羧反应。方法:在喹诺酮类化合物5与邻苯二胺缩合中,以多聚磷酸(PPA)为脱水剂,可以得到3-脱羧产物。结果:反应条件对3-脱羧产物有明显的影响,核磁共振、质谱、红外光谱等与3-脱羧产物的结构相符。结论:为新型喹诺酮类化合物的合成研究和3-脱羧反应的研究提供参考。更多还原

【Abstract】 Objective:To study the decarboxylation of quinolones.Methods:3-decarboxylic quinolones were obtained via condensation of compound 5 with o-phenylenediamine.PPA was used as a dehydration agent.Results:The yield of the target compound was controllable by reactive conditions. The target compound was verified by IR,MS and ~1HNMR.Conclusion:The decarboxylation reaction might offer an alternative route in the synthesis of quinolones.更多还原