【摘要】 目的:比较坦度螺酮与美利曲辛合剂治疗焦虑和抑郁状态的疗效。方法:将合并焦虑和抑郁状态的患者78例随机分为试验组39例(枸橼酸坦度螺酮治疗组,最终完成32例)和对照组39例(美利曲辛合剂治疗组,最终完成34例),进行随机开放平行对照研究,同时用汉密尔顿抑郁量表评分(HAMD)和汉密尔顿焦虑量表评分(HAMA)对其抑郁和焦虑状况进行治疗前及治疗后(第2,4,6周)的评估。结果:治疗组从用药后第2周开始患者HAMA评分显著减少(第2,4,6周均P<0．01),从第4周开始HAMD评分显著减少(第4周P<0．05,第6周P<0．01)。对照组从用药后第2周开始,患者的HAMA评分和HAMD评分均明显减少(均为第2周P<0．05,第4,6周P<0．01)。治疗组HAMA减分差值高于对照组(第4周P<0．05,第6周P<0．01);对照组HAMD减分差值高于治疗组(第2．6周均P<0．01,第4周P<0．05)。结论:坦度螺酮抗焦虑作用优于美利曲辛合剂,而抗抑郁作用则稍弱于美利曲辛合剂。坦度螺酮用于治疗合并广泛性焦虑障碍的严重抑郁症时,应该合并应用其他抗抑郁药。更多还原

【Abstract】 Objective:To compare the efficacy of tandospirone with flupenthixol/melitracen in the treatment of depression with anxiety. Methods:78 patients with depression with anxiety were randomly administered with either tandospirone (re =39 enrolled but 32 completed) or flupenthixol/melitracen (re =39 enrolled but 34 completed) for 6 weeks. The efficacy was evaluated based on Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA) pre-treatment and in 2, 4, and 6 weeks post-treatment. Results:Both regimens significantly reduced the HAMA and HAMD. The tandospirone-treated patients showed a superior improvement in HAMA evaluation but inferior in HAMD evaluation to the flupenthixol/meltracen-treated patients. Conclusion:Adjunctive therapy of tandospirone with other anti-depressants for severe depression with anxiety should be considered.更多还原