【摘要】 [目的]观察加味四逆散对溃疡性结肠炎(UC)肝郁模型大鼠的治疗效果。[方法]采用免疫法及束缚法的复合因素制作UC肝郁大鼠模型,检测加味四逆散各剂量组与模型组整体状态、病理形态学以及髓过氧化物酶(MPO)活性。[结果]加味四逆散各剂量组肉眼观察肠管黏膜皱襞纹理清晰,少见或无糜烂,未见溃疡;镜下见黏膜上皮及腺管排列整齐,极向明显,杯状细胞丰富,间质充血水肿不明显,基本形态与正常组相似;MPO活性明显降低,与模型组比较差异有统计学意义(P<0.01),其中各项指标以加味四逆散中剂量组效果最佳。[结论]加味四逆散对UC肝郁模型大鼠具有显著的修复溃疡及抗炎作用。更多还原

【Abstract】 [Objective] To observe the effect of variant Sinisan(VS) on ulcerative colitis of liver depress type rat model.[Methods] Rat model of ulcerative colitis of liver depress type was made by the methods of ties and immunity.The whole condition,pathomorphism and the myeloperoxidase(MPO) activity were observed in all groups.[Results] The intestinal mucosa folds were clear,with few or no erosion,no ulcer in groups of VS.Under the microscope,epithelium mucosae and cryptae lined up in order with obvious polus,and cup-shaped cell was abundant,mesenchyma engorged and dropsy unconspicuous in groups of VS,which are similar to the normal group.MPO activity decreased obviously,which was significant comparing with model group(P<0.01).The effect of the middle dosage group of VS was better than that of other groups.[Conclusion]VS has conspicuous effect on the recovery of tissue anabrotic and inflammatory in ulcerative colitis of liver depress type rat model.更多还原