【摘要】 目的狼疮性肾炎(LN)患者的血脂异常发生率相当高,本文旨在探讨该人群血脂异常与疾病活动性的关联,以及与心脑血管事件发生的关系。方法分析LN患者血脂与病理类型、24h尿蛋白定量、血肌酐水平(Scr)、SLE疾病活动指数(SLEDAI)及心脑血管事件的关系。结果198例LN患者出现血脂异常为100人(50.5%),IV型和V型LN患者较易发生血脂异常。TG、TC、LDL、apoB、Lp(a)与24h尿蛋白定量呈正相关(P<0.05、P<0.01);Lp(a)与Scr呈正相关(r=0.195,P<0.05)。血脂异常组SLEDAI高于血脂正常组(P<0.05),TG与SLEDAI呈正相关(r=0.249,P<0.05)。100例血脂异常LN患者发生心脑血管事件18人(18%),98例血脂正常患者发生心脑血管事件4人(4%),差异有显著意义(P<0.01)。结论狼疮性肾炎患者易发生血脂异常,且与疾病的活动性有密切关系。血脂异常者尿蛋白量明显增多,而Lp(a)与肾功能有关。此外,血脂异常是LN患者发生心脑血管事件的危险因素。更多还原

【Abstract】 Objective To investigate the correlation of dyslipidemia and the disease activity, and the relation with cardio-cerebral vessel incidents. Methods The correlations of blood lipids and pathological types, 24 hours urine protein, serum creatinine, disease activity index of SLE (SLEDAI), cardio-cerebral vessel incidents in patients with LN were analyzed. Results Dyslipidemia was found in 100 patients(50.5%). Patients with LN of type IV and V mostly had dyslipidemia. TG, Tch, LDL,apoB, lp(a) were correlated with 24 hour urine protein(P<0.05 of <0.01); lp(a) was correlated with Scr(r=0.195,P<0.05). SLEDAI of patients with dyslipidemia was significantly higher than that of patients with normal blood lipids(P<0.05). TG was correlated with SLEDAI(r=0.249, P<0.05). Patients with dyslipidemia had more cardio-cerebral vessel incidents than patients with normal blood lipids(P<0.01). Conclusion Dyslipidemia was often found in patients with LN, which is closely associated with the activity of the disease. Increased urine protein excretion appeared in patents with abnormal blood lipids, and lp(a) was associated with renal function. Furthermore, blood lipids abnormality emerged as a risk factor of cardio-cerebral vessel incidents in patients with LN.更多还原