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大鼠及小白鼠口服多拉菌素的急性毒性试验

ACUTE TOXIC TRIAL OF DORAMECTIN AFTER ORALLY ADMINISTERED TO MICE AND RAT

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【作者】 周绪正张继瑜李剑勇李金善赵宏海王有祥蒲万霞魏小娟

【Author】 ZHOU Xu-zheng~1,ZHANG Ji-yu~1,LI Jian-yong~1,LI Jin-shan~1,ZHAO Hong-hai~2,WANG You-xiang~3,PU Wan-xia~1,WEI Xiao-juan~1(1.Lanzhou Institute of Animal and Veterinary Pharmaceutical Sciences,CAAS,Key Laboratory of New Animal Medicine Project,Ministry of Agricultrure,Lanzhou 730050,China;2.The Animal Quarantine Station of Gansu Province Farming Office,Lanzhou 730030,China;3.The Animal Quarantine Station of Chengguan District Lanzhou City,Lanzhou 730030,China)

【机构】 中国农科院兰州畜牧与兽药研究所农业部新兽药工程重点实验室甘肃省畜牧厅动物检疫站兰州市城关区检疫站中国农科院兰州畜牧与兽药研究所农业部新兽药工程重点实验室 兰州730050兰州730050兰州730030

【摘要】 采用递增法预试测得大鼠和小白鼠口服多拉菌素LD0值依次为5.37 g/kg.BW、3.54 g/kg.BW,LD100值依次为13.91 g/kg.BW、6.19 g/kg.BW,依之按简化寇氏法分组正式试验,统计死亡率,计算出大鼠和小白鼠口服多拉菌素LD50值依次为7.67 g/kg.BW、4.58 g/kg.BW,其95%可信限依次为7.22~8.12 g/kg.BW、3.80~5.50 g/kg.BW。

【Abstract】 With the method of increase by degrees,LD0 and LD100 of doramectin were detected after orally administered to mice and rat.LD0 in turn is 5.37 g/kg.BW,3.54 g/kg.BW,and LD100 is 13.91 g/kg.BW,(6.19) g/kg.BW respectively.According this with the method of Krber-Spearman,we do experiment in groups,calculated LD50 of doramectin after orally administered to mice and rat.LD50 of Doramectin is 7.67 g/kg.BW、4.58 g/kg.BW.It’s 95% credible in turn is 7.22~8.12 g/kg.BW,3.80~5.50 g/kg.BW.

【关键词】 多拉菌素大鼠小白鼠急性毒性试验
【Key words】 Doramectinmiceratacute toxic trial
  • 【文献出处】 中国兽医寄生虫病 ,Chinese Journal of Veterinary Parasitology , 编辑部邮箱 ,2006年04期
  • 【分类号】S859.79
  • 【被引频次】4
  • 【下载频次】197
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