【摘要】 目的探讨胃癌中血管内皮生长因子C(VEGF-C)和基质金属蛋白酶7(MMP-7)的表达及两者与胃癌侵袭和淋巴结转移的关系。方法采用SP免疫组化技术,分别检测6 0例胃癌组织、癌旁组织及3 0例癌周区域淋巴结中VEGF-C及MMP-7的表达水平。结果VEGF-C和MMP-7在胃癌组织中的阳性表达率明显高于正常胃黏膜及癌旁组织;在区域淋巴结癌转移组中的阳性表达率明显高于无癌转移组(P<0.0 1);伴有淋巴结转移的胃癌组织中VEGF-C,MMP-7的阳性表达率明显高于无淋巴结转移组(P<0.0 5);VEGF-C,MMP-7表达与淋巴结转移、淋巴管侵犯、浸润深度、TNM分期有密切关系(P<0.0 5)。结论VEGF-C和MMP-7在胃癌中的高表达与胃癌浸润侵袭程度、淋巴结转移有密切关系。更多还原

【Abstract】 Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and matrix metalloproteinase-7(MMP-7) in gastric carcinoma and their correlation with tumor invasion and(metastasis).Methods Streptavidin peroxidase immunohistochemistry technique(SP)was used to detect the(expression) of VEGF-C and MMP-7 in 60 gastric carcinoma specimens,60 specimens of gastric mucosa(adjacent) to carcinoma,and 30 regional lymph node specimens.Results The positive expression rate of VEGF-C,MMP-7 in gastric carcinoma was markedly higher than that in normal gastric mucosa and gastric mucosa adjacent to carcinoma.The positive expression rates of VEGF-C and MMP-7 in metastatic regional lymph nodes were significantly higher than that in non-metastatic regional lymph nodes(P<0.01).The positive expression of VEGF-C and MMP-7 in gastric carcinoma specmens in patients with lymphatic metastasis was significantly higher than that in without lymphatic metastasis(P<0.05).The positive expression level of VEGF-C and MMP-7 was significantly correlated with lymph node metastasis,lymphatic vessel invasion,tumor infiltration depth and UICC TNM staging(P<0.05).Conclusions The increased expression of VEGF-C and MMP-7 in gastric carcinoma closely correlates with tumor invasion and metastasis.更多还原