【摘要】 目的探讨肺癌患者群体的免疫细胞毒细胞的功能状态。方法应用流式细胞仪检测30例手术前肺癌患者和30例该院健康职工外周血总T淋巴细胞、自然杀伤细胞(NK)、NK样T杀伤细胞(NKT)、γδT细胞和CTL细胞。结果γδT细胞:正常组为(6.54±2.94)%,患者组为(3.58±2.14)%(t=3.730,P=0.001)。CTL细胞:正常组为(17.21±4.49)%,患者组为(10.86±4.67)%(t=5.130,P<0.001);其他被测细胞的百分率,经统计学分析,均无统计学意义。结论特异性免疫杀伤细胞低下对肺癌的发生有重要影响。非特异性免疫细胞毒细胞影响有限。更多还原

【Abstract】 Objective To study the function of NK,NKT,CTL and γδT of the patients with lung cancer.Methods To determine and analyze the total T cells,NK,NKT,CTL and γδT lymphocytes in peripheral blood of the patients with lung cancer and healthy donors by Flow Cytometry.Experiment group consisted of 30 patients with lung cancer.Control group consisted of 30 healthy donors.Results γδT(CD+3γδTCR+)% in control group was(6.54±2.94)%,in experiment group was(3.58±2.14)%(t =3.730,P=0.001);CTL(CD+8CD+28)% in control group was(17.21±4.49)%,in experiment group was(10.86±4.67)%(t =5.130,P<0.001).There was no significance in the others.Conclusion The results suggested that non-special immunocytotoxic cells(NK and NKT) had not significant difference between the two groups,but special immunocytotoxic cells(CTL andγδT) showed notable significance in the population of the lung cancer,which possibly have important function on the development of lung cancer due to dysfunction of CTL and γδT.更多还原