【摘要】 目的:探讨异氟醚对体外循环期间脑氧代谢的影响。方法:24例在体外循环(CPB)下行瓣膜置换术的患者随机分为对照组和异氟醚组。CPB期间异氟醚组经氧合器吸入0.5%~3%的异氟醚,对照组则不吸入异氟醚,于CPB开始前(T1),CPB开始降温至32℃(T2),低温稳定期(T3),复温至32℃(T4)以及CPB结束后10 m in(T5)共5个时段取右颈内静脉血测定颈内静脉血氧饱和度(SjO2),测定动脉血气,计算脑氧摄取率(CEO2)。结果:异氟醚组SjO2值T3与T1时点相比差异有显著意义(P<0.05),对照组T3时点及异氟醚组T2,T3及T4时点CEO2均比T1时点明显下降(P<0.05);T3时段CEO2值异氟醚组与对照组相比差异有显著意义(P<0.05)。结论:异氟醚能防止CPB氧供需失衡。更多还原

【Abstract】 Objective: To observe the effect of isoflurane on the cerebral oxygen supply-demands balance during cardiopulmonary bypass（CPB）.Methods: All of 24 patients undergoing heart valve replacement were randomly divided into control group and isoflurane group,12 cases each.During CPB,Isoflurane group inhaled 0.5%～3% isoflurane through oxygenator,and control group was without inhalation of isoflurane.Jugular bulb blood oxygen saturation（SjO₂）and cerebral oxygen extraction rate（CEO₂） and artery blood gas analysis were measured at five stages（T₁-T₅） of CPB: before CPB（T₁）;bring down the temperature to 32℃（T₂）;cooling stability stage（T₃）;recovery temperature to 32℃（T₄）;10min after CPB. Results: SjO₂ at T₃ was higher significant than at T₁（P<0.05） in isoflurane group.CEO₂ at point T₃ in control group and CEO₂ at point T₂ to T₃ in isoflurane group was markedly higher than that at T₁（P<（0.05））;At 32 ℃（T₄）,CEO₂ of isoflurane group at T₄ was markedly higher than that of control group（P<0.05）. Conclusion: Isoflurane could prevent the imbalance of cerebral oxygen supply and demand during CPB.更多还原