【摘要】 目的探讨慢性前列腺炎的细菌学病因,为临床治疗提供帮助。方法前列腺检测标本取自140例猝死的器官捐献者,年龄20~35岁。取前列腺周围带组织,分成两块,一块作常规病理检查,另一块用聚合酶链反应检测细菌16S rRNA基因。结果32.9%(46/140)的组织病理呈慢性前列腺炎,均为轻度灶性炎症改变,其中间质炎42例,间质伴腺体周围炎3例,腺体周围炎1例。16SrDNA阳性率为19.3%(27/140),其中前列腺炎标本阳性率为48.9%(22/46),非前列腺炎标本阳性率为5.3%(5/94),前列腺炎标本阳性率高于非前列腺炎标本,差异有统计学意义(χ2=36.910,P<0.001)。结论细菌感染可能是引起慢性前列腺炎的重要原因。更多还原

【Abstract】 Objective To investigate the role of bacteria in chronic prostatitis. Methods Complete specimens of prostate were obtained from 140 organ donors, aged 20~35, at autopsy. A piece of tissue was collected from the peripheral zone of prostate from each specimen and was divided into 2 parts to undergo pathological examination and PCR so as to detect the 16S ribosomal RNA (16S rRNA) gene of bacteria.Results Focal mild inflammation was shown in 46 of the 104 specimens (32.9%), including interstitial inflammation in 42 specimens, inflammation in both intersttia and body of gland in 3 specimens, and perigladulitis in 1 specimen. Twenty-seven of the 140 specimens (19.3%) were positive in 16S rRNA gene. The positive rate of 16S rRNA gene of the specimens with prostatitis was 48.9%, significantly higher than that of the specimens without prostatitis (5.3%, P<0.001). Conclusion Bacteria may play an important role in the pathogenesis of chronic prostatitis.更多还原