【摘要】 目的建立我国正常人血清犬尿氨酸(KYN)及犬尿氨酸/色氨酸含量(KT)比值参考值范围。方法采用高效液相色谱-紫外法(HPLC-UV)检测86名健康成人血清KYN和色氨酸(TRP)含量,并计算KT比值。结果正常成人血清KYN为0·364~3·022μmol/L,平均(1·426±0·542)μmol/L,KT比值为11·008~47·528mmol·L-1·M-1,平均(29·271±9·315)mmol·L-1·M-1。不同年龄组之间,血清KYN、TRP含量及KT比值差异均无统计学意义(P>0·05);性别之间,血清KYN、TRP含量及KT比值差异均有统计学意义(P<0·05)。结论建立了健康国人KYN及KT比值参考范围,为相关疾病的辅助诊断、疗效观测及发病机制等研究提供相应参数。更多还原

【Abstract】 Objective To establish the serum reference values of kyurnine(KYN) and kyurnine/tryptophan(KT) ratio in healthy persons.Methods The concentrations of serum KYN and TRP levels in healthy persons were determined by high performance liquid chromatography-ultraviolet (HPLC-UV) and the content ratio of KYN to TRP KT were calculated.Results The serum KYN and KT ratio levels in 86 healthy persons were 0.364-3.022 μmol/L and 11.008-47.528 mmol·L~ -1 ·M~ -1 respectively. In different age groups, it showed no difference in the concentrations of KYN and KT ratio in serum (P>0.05). Butt showed sex difference in concentrations of KYN and KT ratio in serum (P<0.05).And the concentrations KYN and KT ratio were higher in men than women.Conclusion It suggested that the reference values of KYN and KT ratio could be a good indicator in corresponding diseases.更多还原