【摘要】 目的探讨伴有t(8;21)的成人急性髓系白血病(AML)的细胞遗传学特点及预后意义。方法分析我院检测的189例成人t(8;21)的细胞遗传学和临床预后特点。结果单纯t(8;21)(q22;q22)63例,占33.3%;伴有附加异常的126例,占66.7%;单纯性染色体丢失77例占总数的40.7%,其中-Y占男性患者的46.7%(63/135),-X占女性患者的25.9%(14/54)。有附加异常的126例中,单纯性染色体丢失77例(61.1%);9q-16例(12.7%);+4者5例(4.0%);7q-6例(4.8%);四倍体(4N)2例(1.6%);变异易位7例(5.6%)。此组患者的缓解率较高(87.0%),生存期较长(中位生存期21.6个月)。附加异常中+4和4N组预后较差。荧光原位杂交技术是诊断t(8;21)AML较为准确和可靠的方法,特别是对于变异易位、复杂易位和隐匿变异易位的病例。结论t(8;21)常合并附加异常,附加异常的种类会影响t(8;21)AML患者的预后。更多还原

【Abstract】 Objective To investigate the cytogenetic and prognostic significance of acute myeloid leukemia(AML)with t(8;21).Methods 189 patients with t(8;21)AML were categorized according to their additional karyotypic aberration and their clinical outcomes analysed.Results Among them,63 patients(33.3%)were t(8;21)without other additional aberrations,126 cases(66.7%)were t(8;21)with other additional aberrations.-Y was found in 46.7%(63/135)of the male and-X was found in 25.9%(14/54)of female patients.In additional aberrations,loss of the sex chromosome were found in 77 cases(61.1%),Del(9q)was found in 16 cases(12.7%),+4 was found in 5 cases(4.0%);7q[KG-*2]-was found in 6 cases(4.8%);Tetraploidy(4N)was found in 2 cases(1.6%);Variant translocation was found in 7 cases(5.6%).The 189 patients had a high remission rate(87.0%)and a relatively long median survival(21.6 months).+4 and 4N were an unfavorable prognostic factors.Fluorescence in situ hybridization technique is a more sensitive and accurate method to detect t(8;21),especially in variant translocation,complex variant translocation and masked translocation.Conclusion t(8;21)AML is also freguently associated with additional chromosome aberrations,these aberration had influence on prognosis.更多还原