【摘要】 目的研究腰椎间盘 MRI 信号强度与髓核内胶原含量之间的相关性。方法 31例腰椎间盘突出症患者,全部行经皮穿刺腰椎间盘摘除术（PLD）,得到31个髓核样本,用改良羟脯氨酸测定法测定其内胶原蛋白含量;在 MR 矢状面 T₂WI 上测量腰椎间盘髓核及脑脊液的信号强度,计算出二者的比值。分别计算胶原含量与信号强度比值、腰椎间盘 T₂WI 信号强度之间的线性相关系数。结果髓核内胶原含量为（231.0±63.5）mg/g,信号强度比值为0.19±0.07,二者之间的 r 值为-0.61（P<0.01）。腰椎间盘 T₂WI 信号强度为80.5±31.7,胶原含量与其之间的 r 值为-0.53（P<0.01）。结论腰椎间盘 MR 信号强度与髓核内胶原含量之间存在负相关;胶原蛋白增多是导致退变腰椎间盘 T₂WI 信号强度降低的因素之一。更多还原

【Abstract】 Objective To study correlation between MRI signal intensity of the lumbar intervertebral disc and collagen content in the nucleus pulposus.Methods Thirty-one cases with lumbar intervertebral disc herniation（male 21,female 10）received percutaneous lumbar disketetomy.Thirty-one specimens of nucleous pulposus were obtained from percutaneous lumbar disketctomy procedure and collagen content in them was measured with reformed hydroxyproline measurement method.The signal intensity（SI） of lumbar intervertebral disc and cerebrospinal fluid was measured in T₂ WI sagittal image and then ratio of disc SI to cerebrospinal fluid SI was calculated.The Pearson analysis was used to analyze the correlation between the collagen content and SI ratio and disc SI on T₂ WI.Results Collagen content and SI ratio were （231.0±63.5）mg/g and 0.19±0.07,respectively.There was negative correlation between them （r=-0.61,P<0.01）.Disc T₂ WI SI was 80.5±31.7.Collagen content was correlated inversely with Disc T₂ WI SI（r=-0.53,P<0.01）.Conclusion There exits moderately negative correlation between MRI signal intensity and collagen content in the nucleous pulposus.The increasing of collagen content is one of factors to cause signal intensity of disc decreasing.更多还原