【摘要】 以对异丙基苯甲酸为原料,经过氯磺化、还原、甲基化、胍解得到卡立泊来德,总收率为45·3%。改进后的工艺路线,降低了成本,简化了操作和反应条件。更多还原

【Abstract】 Cariporide was synthesized from 4-isopropylbenzoic acid(2 ) as starting material.Compound 2 was treated w ith chlorosulfonic acid to form c orresponding chlorosulfonyl derivative(3)which w as reduced by sodium sulfite,followed by methylation with dimethyl sulfate to gi ve corresponding methyl benzoate(5).Compound wa s treated with guanidine to give compound 1.The overall yield of the improved procedure is 45.3%.The process is simple and practical.更多还原