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海金沙草中一个新的甾体苷类化合物的分离和结构鉴定(英文)

A new steroidal glycoside from Lygodium japonicum

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【作者】 张雷红范春林张现涛殷志琦叶文才

【Author】 ZHANG Lei-hong~(1),FAN Chun-lin~(1),ZHANG Xian-tao~(1),YIN Zhiqi~(1),YE Wen-cai~(1,2)~1Department of Natural Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009;~2Institute of Traditional Chinese Medicine & Natural Products,Jinan University,Guangzhou 510632,Chin

【机构】 中国药科大学天然药物化学教研室中国药科大学天然药物化学教研室 南京210009南京210009暨南大学中药及天然药物研究所广州510632

【摘要】 目的:研究海金沙草(Lygodium japonicum)的化学成分。方法:采用硅胶柱层析、Sephadex LH-20柱层析、ODS柱层析等方法进行分离和纯化化学成分,结合化学方法和波谱方法进行结构鉴定。结果:从海金沙草中分离得到4个化合物,分别为:(24R)-stigmastan-3β,5α,6-tβriol 3-O-β--Dglucopyranoside(1),6-O-p-coumaroyl-D-glucopyranose(2),6-O-caffeoyl-D-glucopyranose(3),and 1-O-(E)-caffeoyl-β-D-gentiobiose(4)。结论:化合物1为新化合物,化合物2,3,4为首次从海金沙科中分离得到。

【Abstract】 Aim:To investigate the chemical constituents from the aerial parts of Lygodium japonicum.Methods:Various chromatographic techniques were employed for isolation and purification of the constituents.The structures were elucidated by chemical evidence and spectral methods.Results:A new stigmasterol glycoside,(24R)-stigmastan-3β,5α,6β-triol 3-O-β-D-glucopyranoside(1),together with three known phenolic glycosides:6-O-p-coumaroylD-glucopyranose(2),6-O-caffeoyl-D-glucopyranose(3),1-O-(E)-caffeoyl-β-D-gentiobiose(4) were obtained and identified by spectroscopic methods.Conclusion:All compounds were isolated from Lygodiaceae for the first time.

【基金】 This project was supported bythe National Natural Science Foundation of China(No.30472146)
  • 【文献出处】 中国药科大学学报 ,Journal of China Pharmaceutical University , 编辑部邮箱 ,2006年06期
  • 【分类号】R284
  • 【被引频次】18
  • 【下载频次】379
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