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尿8-羟基脱氧鸟苷水平与糖尿病肾病的相关性

Determination of urinary 8-hydroxy-guanine levels in diabetes mellitus and its significance in diabetic nephropathy

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【作者】 张霞苏本利王赞峰许国旺姚庆红

【Author】 ZHANG Xia~*,SU Ben-li,WANG Zan-feng,et al.~*Department of Endocrinology,The Second Hospital,Affiliated to Dalian Medical University,Dalian 116027,China

【机构】 大连医科大学附属第二医院内分泌科中国科学院大连化学物理研究所中国科学院大连化学物理研究所 116027116027

【摘要】 正常对照32例和2型糖尿病(T2DM)患者68例,毛细管电泳法测定8-羟基脱氧鸟甘(8-OHdG)。T2DM患者与正常对照组比较,24 h尿8-OHdG水平明显升高(46±43,11±6)且随UAER的增加而增加(UAER<20μg/min组24 h尿8-OHdG含量17±9,UAER 20~200μg/min组34±22,UAER>200μg/min组80±51)。8-OHdG与糖尿病肾病(DN)程度呈正相关,偏回归系数1.09,95%CI1.02~1.17,P=0.01。

【Abstract】 To explore the levels of 24 hr urinary 8-hydroxyguanine(8-OHdG)in diabetes mellitus and its association with diabetic nephropathy(DN).In 32 healthy subjects and 68 type 2 diabetic patients,8-OHdG was measured with high performance capillary electrophoresis.Urinary 8-OHdG levels were significantly higher in type 2 diabetic patients and increased with increment of urinary albumin excretion rate.The levels of 24 hr urinary 8-OHdG can evaluate the systemic oxidative stress,and the degree of 8-OHdG is correlated with the degree of DN.

  • 【文献出处】 中国糖尿病杂志 ,Chinese Journal of Diabetes , 编辑部邮箱 ,2006年01期
  • 【分类号】R587.2
  • 【被引频次】22
  • 【下载频次】310
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