【摘要】 目的了解国产不同剂量重组乙型肝炎(乙肝)疫苗(酵母)阻断乙肝病毒(HBV)母婴传播的效果。方法用5μg/0.5ml和10μg/0.5ml重组乙肝疫苗(酵母)免疫乙肝病毒表面抗原(HBsAg)、乙肝病毒膜抗原(HBeAg)双阳性母亲的新生儿68例,采用0、1、6个月接种程序,用固相放射免疫(SPRIA)法定量检测乙肝病毒表面抗体(抗-HBs)滴度及HBsAg。结果全程免疫后1个月,10μg剂量组新生婴儿HBsAg阳性率为2.86%,保护率为96.43%;5μg剂量组的HBsAg阳性率为3.45%,保护率为95.69%。10μg、5μg剂量组的抗-HBs阳转率分别为97.14%、82.76%,产生的抗-HBs几何平均浓度分别为237.44毫国际单位/毫升(mIU/ml)、150.06mIU/ml。10μg组的抗体阳转率明显高于5μg组。结论重组乙肝疫苗(酵母)母婴阻断效果良好,10μg组的免疫原性高于5μg组。更多还原

【Abstract】 Objective To study the efficacy of different doses yeast-derived Hepatitis B vaccine(YDV)to neonates born to HBsAg,HBeAg carrier mother.Methods 68 neonates born to HBsAg,HBeAg carrier mother were vaccined in two groups(5 μg dose and 10 μg dose) by 0,1,6 month schedule.Result Vaccined newborns HBsAg positive rate of 10 μg group is 2.86%,the protective rate is 96.43%;HBsAg positive rate of 5 μg group is 3.45%,the protective rate is 95.69%.The anti-HBs seroconversion rate is 97.14%,82.76%,the mean geometric concentration(GMC)of anti-HBs is 237.44 mIU/mL and 150.06 mIU/mL after 1 month of full vaccination schedule in 10 μg dose group and 5 μg dose group respectively.Conclusion The effective anti-HBs conversion rates in 10 μg dose group is significantly higher than 5 μg dose group.These results revealed the high efficacy of YDV.更多还原