【摘要】 目的:探讨子宫内膜异位症患者腹腔液中可溶性细胞间粘附分子-1(sICAM-1)的表达情况。方法:收集子宫内膜异位症患者腹腔液30份及非子宫内膜异位症患者中正常盆腔对照组Ⅰ的腹腔液12份、盆腔炎致盆腔粘连对照组Ⅱ的腹腔液13份,应用酶联免疫吸附试验双抗体夹心法(ELISA)测定腹腔液sICAM-1的表达;结果均用方差分析和t检验进行统计处理。结果:子宫内膜异位症患者腹腔液中sICAM-1水平明显高于正常对照组,与盆腔粘连对照组差异不显著。结论:子宫内膜异位症患者腹腔液细胞间粘附分子的异常表达可能为异位内膜的生存、生长提供免疫抑制的盆腹腔环境,而盆腔炎则可能是子宫内膜异位症发生的促进因素。更多还原

【Abstract】 Objective:To study the relationship between intracellular adhesion molecule-1(ICAM-1) and endometriosis.Methods:The expression of sICAM-1 protein were determined by enzyme-linked immunosorbent assays(ELISA) in 30 peritoneal fluid(PF) of patients with endometriosis and 12 PF from normal pelvic cavity/13 PF from non-endometriosis subjects with pelvic adhesion during the same menstrual phase.And then analyzed by F test and t test.Results:The expression of sICAM-1 in PF from patients with endometriosis was significantly higher than those in normal controls,but has no differences with those pelvic adhesion non-endometriosis subjects.Conclusion:The overexpression of sICAM-1 in PF promotes immunotolerance to implanted tissue in the peritoneal environment.In patients with endometriosis,pelvic inflammation may accelerate the developing of endometriosis.更多还原