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Characterization of a novel impurity in bulk drug of lisinopril by multidimensional NMR technique

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【Author】 WANG Dan-hua1,2, PEI Sai-feng1, ZHOU Ming-hua2, SUN Cui-rong1, PAN Yuan-jiang1 (1Department of Chemistry, Zhejiang University, Hangzhou 310027, China) (2Zhejiang Huahai Pharmaceutical Co., Ltd., Linhai 317024, China)

【Abstract】 During the routine impurity profile of lisinopril bulk drug by HPLC (high-performance liquid chromatography), a potential impurity was detected. Using multidimensional NMR (nuclear magnetic resonance) technique, the trace-level impurity was unambiguously identified to be 2-(-2-oxo-azocan-3-ylamino)-4-phenyl-butyric acid after isolation from lisinopril bulk drug by semi-preparative HPLC. Formation of the impurity was also discussed. To our knowledge, this is a novel impurity and not reported elsewhere.

【关键词】 Lisinopril； Impurity； Structural characterization； NMR；
【Key words】 Lisinopril； Impurity； Structural characterization； NMR；
【基金】 Project (No. 20375036) supported partly by the National NaturalScience Foundation of China
  • 【文献出处】 Journal of Zhejiang University Science ,浙江大学学报(英文版) , 编辑部邮箱 ,2006年04期
  • 【分类号】TQ460.7
  • 【下载频次】27
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