【摘要】 目的:探讨赤芍甘草冲剂对D-半乳糖胺(D-GalN)致小鼠急性化学性肝损伤的保护作用及可能机制。方法:建立D-GalN诱导小鼠化学性肝损伤模型,分光光度法检测血清中丙氨酸氨基转移酶(ALT)、天冬门氨酸氨基转移酶(AST)水平和肝匀浆丙二醛(MDA)、一氧化氮(NO)含量。结果:赤芍甘草冲剂(200、400、800 mg.kg-1)灌胃给药均能降低血清中升高的转氨酶水平,使升高的肝脾指数降低;同时发现赤芍甘草冲剂可降低肝匀浆中升高的MDA和NO水平。结论:赤芍甘草冲剂对D-GalN致小鼠急性化学性肝损伤具有保护作用,其机制与其抗氧化活性等有关。更多还原

【Abstract】 AIM: To investigate the effects of Chishaoganaochongji D-galactosamine-induced liver injury in mice.METHODS: The chemical-associated liver injury in mouse was induced made by administration of D-GalN.The serum alanine aminotransferase（ALT） and aspartate aminotransferase（AST） level,and malondiadehyde（MDA） and nitric oxide（NO） level in liver homogenate were assayed by chemochromometry.RESULTS:Chishaogancaochongji(200,400,800(mg·kg^-1)) was able to decrease levels of serum transaminases（ALT,AST）,liver index and thymus index significantly.Furthermore,Chishaogancaochongji also decreased MDA content and NO level in liver homogenate.CONCLUSION: Chishaogancaochongji has protective effect on chemical-associated liver injury in mice.更多还原