【摘要】 目的：观察艾司氟比洛芬凝胶的抗炎镇痛作用。方法：采用二甲苯诱导小鼠耳肿胀,用棉球诱导大鼠肉芽肿,观察艾司氟比洛芬凝胶的抗炎作用；用热板法和扭体法观察艾司氟比洛芬凝胶对小鼠和大鼠的镇痛作用。双氯芬酸乳胶剂(1%)作为阳性对照药,以2%,1.5%和1%的艾司氟比洛芬凝胶分组给药。结果：2%和1.5%艾司氟比洛芬凝胶对二甲苯引起的小鼠耳肿胀有较好的抑制作用(P＜0.01),在给药后30,45 min均能明显提高热板法小鼠的痛阈,改善痛阈提高百分率(P＜0.01,P＜0.05)。2%,1.5%和1%艾司氟比洛芬凝胶对大鼠棉球肉芽肿的形成有一定的抑制作用(P＜0.01)；对1%醋酸引起的大鼠痛反应有较好的抑制作用(P＜0.01)。结论：艾司氟比洛芬凝胶对大鼠及小鼠的炎症及痛反应模型均有抑制作用。更多还原

【Abstract】 AIM:To study the anti-inflammatory and analgesic effect of esflurbiprofen gel.METHODS: Animal models of acute and subacute inflammations(granuloma)were induced respectively by dimethyl benzene in mice and cotton ball in rats to observe the anti-inflammation effect of esflurbiprofen gel,while hot-plate test and writhing test were adopted to study the analgesic effect of esflurbiprofen gel.Animals were grouped according to the administration of 2%,1.5% and 1% esflurbiprofen gel,with diclofenac emulsion(1%)taken as positive control.RESULTS:In mice,2% and 1.5% esflurbiprofen gel could reduce ear edema(P＜0.01)and elevate percentage of pain threshold for hot-plate test at 30,45 min after drug administration(P＜0.01,P＜0.05). 2%, 1.5% and 1% esflurbiprofen gel could suppress granuloma(P＜0.01),alleviate the pain caused by acetic acid in rats(P＜0.01). CONCLUSION:Esflurbiprofen gel possesses obvious anti-inflammatory and analgesic effects.更多还原