【摘要】 目的:比较静脉用胺碘酮和毛花甙C治疗阵发性房颤(PAF)的即时疗效和安全性。方法:84例发作时间在 24～72 h的PAF患者被随机分为胺碘酮组和毛花甙C组(每组42例),分别静脉内给予胺碘酮150～1180 mg和毛花甙C 0．4～0．8 mg。结果:胺碘酮和毛花甙C PAF转复率分别是83．3％和42．9％(P<0．01);未转复者的心室率在胺碘酮组由(128．4±12．3)降至(87．8±11．4)次／min(P<0．01),毛花甙C组由(129．6±13．1)降至(90．3± 11．9)次／min(P<0．01)。两组均无严重副作用发生。结论:静脉用胺碘酮治疗阵发性房颤有效且安全,其转复率显著高于毛花甙C。更多还原

【Abstract】 Objective:To compare the acute efficacy and safety of intravenous amiodarone and cedilanid in the treatment of paroxysmal atrial fibrillation (PAF). Methods: The 84 PAF patients which PAF duration was 24-72 h were average divided into amiodarone group and cedilanid group. Amiodarone 150-1180 mg and cedilanid 0. 4-0. 8 mg were given intravenously respectively. Results:The rate of conversion to sinus rhythm was 83. 3% by amiodarone group and 42. 9% by cedilanid group; its difference was significant (P<0. 01). The ventricular rate in no reverted patients were decreased from (128. 4±12. 3) to (87. 8±11.4) times/min by amiodarone (P<0. 01) and from (129.6±13. 1) to (90. 3±11. 9) times/min (P<0. 01) by cedilanid. No sever side effects were found in two groups. Conclusion: Intravenous amiodarone is effective and safe in the treatment of paroxysmal atrial fibrillation; its reverted rate is significantly higher than cedilanid.更多还原