【摘要】 报道了合成的8种4,6-二甲基嘧啶-2-硫代乙酸的稀土配合物,通过元素分析、摩尔电导、红外光谱、核磁共振氢谱和热重-差热分析,确定了配合物的组成和结构,结果表明,配合物的组成为LnL3.nH2O,其中HL=4,6-二甲基嘧啶-2-硫代乙酸,Ln=La,Ce,Pr,Nd,Sm,Eu,Gd,Tb,n=4或5。在配合物中配体羧基脱去质子后采用螯合双齿的方式与稀土离子形成配位键,同时,配合物中含有4或5个结晶水。抗肿瘤活性研究表明,部分配合物对常见的HL-60人白血病细胞、BGC-823人胃癌细胞、Bel-7402人肝癌细胞、Hela人宫颈癌细胞的抗肿瘤活性明显强于配体。更多还原

【Abstract】 Eight rare earth metal（Ⅲ） complexes with 2-（（（4,6-dimethyl）-2-pyrimidinyl）thio）-acetic acid,LnL₃·nH₂O [HL=2-（（（4,6-dimethyl）-2-pyrimidinyl）thio）-acetic acid;Ln=La,Ce,Pr,Nd,Sm Eu,Gd,Tb;n=4 or 5],were prepared and characterized by elemental analysis,complexometric titration,thermal analysis,conductivity,IR,（）¹H-NMR.The results reveal that carboxyl group of the ligand coordinates with rare earth ions in bidentate mode after deprotonated.The water molecules exist as crystal water in the complexes.The anti-tumour activities of HL and some complexes were tested by both the MTT and SRB methods.The results show that the suppression ratios of some complexes against the tested tumour cells（HL-60 human leukemia cell lines,BGC-823 human gastric carcinoma cell lines,hela human cervix adenocarcinoma cell lines and Bel-7402 human hepatic carcinoma cell lines） are superior to HL.更多还原