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HPV16、HSV-2感染在子宫颈病变中的病理学意义
Study on pathological signification of Cervical diseases infected by HPV16 and HPV-2 of Uygur and Hans women in Xinjiang
【摘要】 目的:探讨人乳头状瘤病毒(HPV16)、单纯疱疹Ⅱ型病毒(HSV-2)与子宫颈病变性质的病因发病学关系。方法:应用免疫组化LSAB法对24例子宫颈湿疣、24例子宫颈上皮内瘤(CIN)和53例子宫颈浸润性鳞癌 (SCC)组织进行HPV16、HSV-2检测。结果:在子宫颈湿疣、CIN、SCC中HPV16检出率分别为62.5%、25.0%、 66.0%;HSV-2检出率分别为83.3%、41.6%、56.6%;HPV16、HSV-2同时检出阳性率分别为54.1%、16.6%及 43.3%。HPV16检出率随CIN、SCC病理分级增高而增加,不同民族的HPV16检出率差异无统计学意义。结论: HPV16感染是子宫颈癌发病的重要因素,且HSV-2在子宫颈鳞癌的发病中具有协同作用。
【Abstract】 Objective:To study the relationship between HPV16, HSV-2 infection and human cervical lesions. Methods:Detection of HPV16, HSV-2 in women patients with cervical intraepithelial neoplasia (CIN) 24, condyloma 24, and invasive squamous cell carcinoma (SCC) 53 by immunochenlistry were carried out respectively. Results: The detected frequencies of HPV16 were 25. 0% (6/24), 62. 5% (15/24) , and 66. 0% (35/53) in CIN, condyloma, and SCC respectively; the HSV-2 were 41. 6% (10/24) , 83. 3% (20/24) and 56. 6% (30/53) in CIN, condyloma, and SCC respectively. The frequency of HPV16 was higher in CIN-Ⅲ and SCC than in others. However, no statistic difference of these virogenes infection between Uygur and Hans women was found. Conclusions: HPV16 may be a critical etiologic factor for cervical carcinogenesis in human beings; HSV-2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer; The frequency of HPV16, HSV-2 in cervical neplastic lesions no statistic difference in Uygur and Hans women in Hami was found.
【Key words】 HPV16; HSV-2; cervical neoplastic lesions; immunochemstry;
- 【文献出处】 新疆医科大学学报 ,Journal of Xinjiang Medical University , 编辑部邮箱 ,2006年01期
- 【分类号】R711.7
- 【下载频次】72