【摘要】 目的:了解北京地区2740人1992—2002年10年间血清胆固醇平均水平和高胆固醇血症患病率的变化情况。方法:1992年在北京大学社区和首钢地区35～64岁人群中进行基线危险因素的抽样调查并建立了心血管病研究队列。2002年对参加第一次危险因素调查的人(45～74岁)采用相同的内容和方法进行了第二次危险因素调查,对2次调查资料完整的2740人的血清胆固醇检查结果进行分析。结果:1.男性血清胆固醇平均水平从4.76mmolL(183.7mgdL)增加到5.19mmolL(200.4mgdL)(P<0.01),增加了9.1%,各年龄组增加的幅度相似;女性总胆固醇的平均水平从4.67mmolL(180.3mgdL)增加到5.52mmolL(213.2mgdL)(P<0.01),增加了18.2%,其中35～44岁年龄组增加最多(20.3%)。2.男性高胆固醇血症的患病率从17.2%增加到35.7%(P<0.01),增加了107.6%,其中35～44岁年龄组增加最多(142.1%);女性高胆固醇血症的患病率从14.4%增加到44.3%(P<0.01),增加了207.6%,其中35～44岁年龄组增加最多(427.0%)。3.1992年血清胆固醇水平<5.20mmolL(200mgdL)、(5.23～5.69)mmolL[(200～219)mgdL]和≥5.72mmolL(220mgdL)者,10年后分别有22.1%、62.1%和70.9%的人血清胆固醇水平≥5.72mmolL(220mgdL)。结论:10年间个体血清胆固醇的平均水平和高胆固醇血症的患病率均明显增加,以35～44岁年龄组人群增加最为明显;随着基线血清胆固醇水平的增加,10年后高胆固醇血症的患病率增加。更多还原

【Abstract】 Objective:To explore the changes of individual serum cholesterol level and the prevalence of hypercholesterolemia in Beijing from 1992 to 2002.Method:In this prospective study, the baseline survey was carried out in 2740 subjects aged 35-44 in 1992 in Beijing. In 2002, the same subjects were surveyed again. Data were analyzed for 2 740 subjects with complete records of the two surveys.Result:1. The mean level of TC increased from 183.7 mg/dL to 200.4 mg/dL in male, and from 180.3 mg/dL to 213.2 mg/dL in female. 2. The prevalence of hypercholesterolemia increased from 17.2% to 35.7% in male, and from 14.4% to 44.3% in female. 3. For subjects with baseline TC level <200 mg/dL, 200-219 mg/dL and ≥220 mg/dL, The rate of hypercholesterolemia after ten years were 22.1%, 62.1% and 70.9%, respectively.Conclusion:The mean level of TC increased significantly in a period of ten years and the prevalence of hypercholesterolemia also increased. The prevalence of hypercholesterolemia increased with the baseline level of TC.更多还原