【摘要】 目的:探讨女性乳腺癌的危险因素,为有效的预防控制措施的建立提供依据。方法:应用成组病例对照的研究方法,收集经组织病理学确诊为乳腺癌的女性病例121名及社区来源的健康女性对照211名。采用统一的问卷调查表获取病例和对照乳腺癌相关危险因素的信息。采用非条件logistic回归进行单因素和多因素分析。结果:多因素分析:与乳腺癌发病有关的变量为吸烟、未足月产次数多及家禽肉类摄入量多,OR值及95%CI分别为15.093(1.014~224.622)、1.759(1.006~3.073)和1.811(1.024~3.203);对乳腺癌有保护作用的变量是奶制品及豆制品摄入量多,OR值及95%CI分别为0.763(0.624~0.933)和0.626(0.422~1.044)。经分组分析,绝经组奶制品摄入量多具有保护作用;非绝经组奶制品及豆制品摄入量多具有保护作用,而吸烟增加患乳腺癌的危险。结论:吸烟、未足月产次数多、家禽肉类摄入量多是乳腺癌的危险因素,奶制品及豆制品摄入量多是乳腺癌的保护因素。更多还原

【Abstract】 Objective:To study the major risk factors of female breast cancer in Sichuan,a case control study was designed.Methods:121 breast cancer patients with histopathological diagnosis and 211 healthy community controls were included.All data were collected with a unified questionnaire.Unconditional logistic regression model was used to analyzed the significant risk factors.Results:Active smoking,abortion,taking poultry,milk and soybean food frequently were related to breast cancer,the ORs were 15.093(1.014～224.622)、1.759(1.006～3.073),1.811(1.024～3.203),0.763(0.624～0.933)and 0.626(0.422～1.044),respectively.Subgroup analyses showed that taking milk frequently can decrease risk of breast cancer in postmenopausal women,while risk in pre-menopausal women were associated with milk intake,soybean food intake and smoking.Conclusion:Taking poultry frequently,abortion and active smoking are risk factors for breast cancer,while taking milk and soybean food frequently have beneficial effects of protecting individual from breast cancer.更多还原