【摘要】 目的:探讨维吾尔族2型糖尿病颈动脉粥样硬化相关的危险因素。方法:收集2003-01/2005-05在新疆医科大学第一附属医院收治的146例维吾尔族2型糖尿病患者,进行颈动脉B超检查,测定内中膜厚度及有无粥样硬化斑块,以内中膜厚度>度1.2mm为斑块形成标准。记录临床资料,计算体质量指数,测定糖化血红蛋白、血压、总胆固醇、三酰甘油、高、低密度脂蛋白胆固醇、脂蛋白α、凝血酶原时间、活化部分凝血酶原时间、凝血酶时间和纤维蛋白原。结果:146例全部完成测试进入结果分析。①颈动脉粥样硬化的检出率为51.8%,146例根据有无颈动脉粥样硬化分为2组:粥样硬化组76例和非粥样硬化组70例。②粥样硬化组年龄、病程、总胆固醇、低密度脂蛋白胆固醇、纤维蛋白原显著高于非粥样硬化组[(57.75±3.46),(51.21±3.23)岁;(5.52±0.58),(4.45±0.43)年;(4.72±0.47),(4.21±0.56)mmol/L;(3.29±0.53),(2.33±0.45)mmol/L;(4.52±0.76)(3.49±0.49)g/L;P均<0.05]。③多元Logistic回归分析显示,年龄、低密度脂蛋白胆固醇、纤维蛋白原进入方程,且OR值均大于1,P<0.01。结论:年龄、低密度脂蛋白胆固醇和纤维蛋白原是维吾尔族2型糖尿病颈动脉粥样硬化的独立危险因素。更多还原

【Abstract】 AIM: To analyze the relative risk factors of carotid atherosclerosis (ATS) in type 2 diabetes mellitus (DM) of Uygur people. METHODS: A total of 146 Uygur patients of type 2 DM were selected from the First Affiliated Hospital of Xinjiang Medical University from January 2003 to May 2005. All the patients underwent carotid artery B-mode ultrasonography were adopted to detect their intima-media thickness (IMT) and ascertain atherosclerotic plaque, taking IMT > 1.2 mm as the standard. According to the clinical data, all the patients were measured body mass index, glycosylated haemoglobin, blood pressure, total cholesterol (TC), triglyceride, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), α-lipoprotein, prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen (Fg). RESULTS: All 146 patients completed the tests and entered the result analysis.①The detectable rate of carotid ATS in Uygur patients was 51.8%. And the patients were divided into ATS group (n=76) and non-ATS group (n=70) according to the appearance of ATS.②The levels of age, durations of DM, TC, LDL-C and Fg in patients with ATS group were significantly higher than that of non-ATS group [(57.75±3.46), (51.21±3.23) years old; (5.52±0.58), (4.45±0.43) years; (4.72±0.47), (4.21±0.56) mmol/L; (3.29±0.53), (2.33±0.45) mmol/L; (4.52±0.76), (3.49±0.49) g/L; P < 0.05].③The multiple Logistic analysis showed that age, LDL-C and Fg were involved in the equation (OR > 1, P < 0.01). CONCLUSION: Age, LDL-C and Fg are the independent risk factors of carotid ATS in type 2 DM of Uygur patients.更多还原