【摘要】 目的:观察超声电丛刺头穴丛刺法治疗急性脑梗死的效果,以及治疗前后体感诱发电位指标及血液生化指标变化。方法:①选择2003-01/2005-06在沈阳脑科医院神经内科住院的急性脑梗死患者261例,男160例,女101例。均为首次患病,且对治疗方案知情同意。将上述患者随机分为2组:丛刺治疗组131例,对照组130例。②丛刺治疗组:采用超声电丛刺治疗仪于头部电丛刺顶区(运动区),以100～200Hz疏密波电针通过6～8h,1次/d,1个疗程30次。对照组:均予以常规脑血管病药物同等治疗。丛刺治疗组和对照组均干预30d。两组疗效判定标准:治疗后神经功能缺损评分减少91%～100%为基本恢复,减少46%～90%为显著进步,减少18%～45%为进步。③采用酶联免疫法测定血浆α-颗粒膜蛋白水平;应用放射免疫法测定血浆血栓素A2水平;采用酶联免疫吸附法双抗体夹心法测定血浆D-二聚体水平;采用免疫透射比浊方法测定脂蛋白(a)水平。应用神经电生理检测仪检测体感诱发电位。④计数和计量资料差异比较采用χ2检验和t检验。结果:急性脑梗死患者261例均进入结果分析。①丛刺治疗组131例中:基本恢复31例,显著进步80例,进步15例,总有效率为96%(126/131);对照组130例:基本恢复14例,显著进步68例,进步12例,总有效率为72%(96/130);丛刺治疗组总有效率明显高于对照组(P<0.01)。②丛刺治疗组治疗后血浆α-颗粒膜蛋白、血栓素A2、D-二聚体和脂蛋白(a)含量较治疗前明显降低(P<0.01)。③丛刺治疗组治疗后体感诱发电位的波潜伏期与传导时间较治疗前明显缩短(P<0.01)。结论:超声电丛刺治疗急性脑梗死效果显著,可显著改善急性脑梗死患者体感诱发电位指标及血液生化指标。更多还原

【Abstract】 AIM: To observe the effect of the scalp ultrasonic electric acupuncture therapy on the acute cerebral infarction, and the changes of somatosensory evoked potential (SEP) and blood biochemical indexes before and after treatment. METHODS: ①A total of 261 inpatients (160 males and 101 females) with acute cerebral infarction in the Department of Neurology, Shenyang Brain Hospital from January 2003 to June 2005 were selected. All the patients, who suffered from the cerebral infarction for the first time, agreed the therapic schedule. They were randomly assigned into two groups: electric acupuncture group (n=131) and control group (n=130). ②Electric acupuncture group: The patients were conducted scalp electric cluster acupuncture on top area (motion area) with the ultrasonic electric acupuncture therapy system, followed 100-200 Hz wave electric acupuncture for 6-8 hours, once daily, 30 times as one course. Control group: All patients were given routine medication treatment for cerebrovascular diseases. Both of the two groups were interfered 30 days. The curative effect standard: it meant nearly recovered if the scores of the nervous function defect decreased 91%-100%, significantly improved with 46%-90% decrease, improved with 18%-45% decrease. ③The level of plasma α-granular membrane protein (GMP) was detected with the enzyme-linked immunosorbent assay (ELISA); the thromboxane A2 (TXA2) with the radio immunoassay; the D-dimer with the Double Antibody Sandwich-ELISA method; the lipoprotein (a) [Lp(a)] with the immuno Turbidmetric method and the SEP with the nerve eletrophysiological tester. ④The χ2 test and t test were used in the comparison of the difference of the count data and measurement data. RESULTS: All the 261 patients entered the result analysis. ①The electric acupuncture group: 31 cases were nearly recovered, 80 cases significantly improved and 15 cases improved, the effect rate was 96% (126/131); the control group: 14 cases nearly recovered, 68 cases significantly improved and 12 cases improved, the effect rate was 72% (96/130); the whole effective rate of the electric acupuncture group was significantly higher than the control group (P < 0.01). ②GMP, TXA2, D-Dimer and Lp(a) of the electric acupuncture group decreased than before treatment (P < 0.01). ③The wave incubation period and conductive time was obviously shorter than before treatment (P < 0.01). CONCLUSION: The ultrasonic electric acupuncture therapy appears to be effective in treatment of the acute cerebral infarction, which obviously improves the SEP and blood biochemical indexes in patients with cerebral infarction.更多还原