【摘要】 调节性T细胞是一群具有免疫调节(或免疫抑制)作用的细胞,Foxp3+CD4+CD25+调节性T细胞约占CD4+T细胞的5%￣15%,主要是CD4+CD8-CD25-单阳性胸腺细胞在胸腺的自然选择过程中产生的,也可以通过外周诱导而产生。它通过细胞接触依赖机制和抑制性细胞因子依赖机制主动抑制自身免疫T细胞的活化,维持自稳状态。现对Foxp3+CD4+CD25+T细胞群的一些特征性分子在其效应机制中的作用进行综述。更多还原

【Abstract】 The crucial role of regulatory cells in self-tolerance and autoimmunity has been clearly established, and much focus has been placed on CD4+ CD25+ regulatory T cells, which comprise approximately 5%–15% of the peripheral CD4+ T cells in human and mice. The naturally occurring regulatory T cells are found to be functionally mature in the thymus, and exert suppression in a contact-dependent manner ex vivo. Some CD4+CD25– T cells can express regulatory activity selectively upon induction and in the context of particular environmental molecules such as cytokines through the activation of forkhead/winged helix transcription factor. Understanding the development and regulatory functions of CD4+CD25+ T regulatory cells may elucidate the etiology for loss of self- tolerance. This review will summarize the molecules involving in the regulatory mechanisms and functions of CD4+CD25+ regulatory T cells.更多还原