【摘要】 目的阐明沈阳和重庆两地一般人群血清中全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)污染水平,比较两地人群血清中PFOS和PFOA分布特征。方法采集沈阳和重庆地区无职业性PFOS和PFOA暴露人群血清,采用高压液相色谱-质谱仪联机系统测定血清中PFOS和PFOA含量。结果沈阳地区一般人群血清中PFOS和PFOA浓度中位数分别为22·40μg/L和4·32μg/L,重庆地区分别为7·40μg/L和1·00μg/L。沈阳地区人群血清中PFOS、PFOA浓度明显高于重庆地区(P<0·01)。两地区女性人群血清中PFOS和PFOA浓度均高于男性水平,沈阳地区人群血清中PFOS浓度男、女性别间差异显著(P<0·05)。重庆地区女性人群血清中PFOS、PFOA浓度与年龄呈正相关关系(rPFOS=0·298,rPFOA=0·271),50岁以上女性人群的相关程度大于13岁以下和13~50岁年龄组。结论沈阳和重庆两地人群血清中PFOS和PFOA污染水平具有显著的地区性差异和分布特征,血清中PFOS和PFOA水平与年龄存在相关性。更多还原

【Abstract】 Objective The purpose of this investigation was to illustrate the perfluorooctane sulfonate (PFOS) and perfluorooctane acid (PFOA) levels in serum of non-occupational exposure human from Shenyang and Chongqing areas and to compare the distributing character and region difference of PFOS and PFOA in those two region human. Methods Sera samples of non-occupational human from Shenyang and Chongqing areas were collected, and the concentration of PFOS and PFOA in serum were measured by High Performance Liquid Chromatography/ Mass Selective Detector(HPLC/MS-MIS). Results The average Shenyang and Chongqing fluorochemical concentrations, respectively, were as follows: PFOS, 22.40μg/L vs 7.40μg/L, PFOA, 4.32μg/L vs 1.00μg/L. Statistical analysis indicated that serum concentrations of PFOS and PFOA were significantly (P<0.01) higher in Shenyang human than in Chongqing human. Furthermore, there are sex differences in PFOS and PFOA concentrations in serum at all location. In Shenyang the concentration of PFOS in females were significantly (P<0.05) higher than in males. The correlations of PFOS (r=0.298) and PFOA (r=0.271) with age were significant in females from Chongqing area, and especially the correlations were higher in older females(age≥50) than the groups of age <13 and 13-50 years old. Conclusion This finding suggests that there are predominant regional differences and distributing character for both PFOS and PFOA concentrations in Shenyang and Chongqing areas, and the concentrations of PFOS and PFOA in serum were correlated with age and sex.更多还原