【摘要】 目的探讨缺氧条件下急性和慢性肺动脉高压(pH)大鼠肺动脉(PA)血管生物力学参数的变化。方法建立大鼠急性和慢性低氧pH动物模型,观察其PA展开角;进行左PA及左上PA血管的载荷试验,计算血管应力-应变关系。结果PA展开角与PA压之间存在密切关系,急性与慢性pH大鼠PA血管应力-应变曲线较对照组平直,PA应变的物质常数α0、α1、α2与应力的物质常数b0、b1、b2的绝对值均明显低于对照组(P<0.05~0.001)。结论结果提示急、慢性pH时PA血管力学性质的变化为PA压力增高与PA血管重构之间关系提供了一种定量分析手段。更多还原

【Abstract】 Objective To investigate changes of mechanical properties of pulmonary hypertension（pH） in pulmonary artery（PA）,the mechanical data of PA in acute and chronic pH were colleted in rat with hypoxic hypertension.Methods Opening angles of PA in hypoxic pH rats were measured.Stress and strain in left PA and left upper PA was obtained by biomechanical loading test.Results There were good relations between opening angles of PA in both hypoxic pH groups.The absolute values of material constants α₀、α₁、α₂ from strain curves and b₀、b₁、b₂ from stress curves decreased significantly in both acute and chronic pH groups compared with those in the control（P<0.05-0.001）.Conclusion Our observation indicated that changes in mechanical properties in both acute and chronic pH could provide an useful approach to quantitatively analyze the relationship between increased PA pressure and the remodeling processes of PA vessels.更多还原