【摘要】 目的对乙酸龙脑酯滴丸的制备工艺进行研究。方法采用正交实验法研究滴丸成型的最佳工艺条件。结果以选择PEG4000∶PEG6000(2∶1)混合液作为基质,药物∶基质以1∶4配比,料温为70℃,液体石蜡为冷却剂,冷凝液温度为10℃,滴口内外径为2.5/2.9(mm/mm),滴口距冷液面3 cm,滴速40 d/m in为最佳条件。结论该工艺可为乙酸龙脑酯滴丸的制备提供实验依据。更多还原

【Abstract】 Objective To study the technological preparation of Borny1 Acetate Dropping Pills.Methods Orthogonal test was applied to optimize the preparation of Bornyl Acetate dropping pills.Results The optimized project was as follows:the matrix contained PEG4000∶PEG6000(2∶1);the rate of Bornyl Acetate to matrix was 1∶4 and the temperature of limonene was 70℃.The refrigerant was liquid paraffin;the internal and external diameters of burette were 2.5 mm and 2.9mm,respectively.The burette was 3cm above the surface of refrigerant;drug was dropped into refrigerant of 10℃ at 40 drops per minute.Conclusion The results provide the data for the ascertainment of shaping operation of Borny1 Acetate Droping Pills at the manufacturing scale.更多还原