【摘要】 目的探讨妈富隆及二甲双胍联合治疗多囊卵巢综合征(PCOS)的疗效。方法93例PCOS患者随机分为妈富隆组、二甲双胍组及妈富隆与二甲双胍联合用药组,每组各31例。比较用药前及用药12周后卵巢刺激素(FSH)、黄体生成素(LH)、睾酮(T)、空腹血糖(FBG)及空腹胰岛素(FI)的变化。结果治疗12周后,妈富隆组治疗前后FSH、FBG0h、FBG1 hF、BG2 h、FI 0 h、FI1 hF、I2 h无显著性差异(P>0.05),治疗后LH、T均低于治疗前,差异具有显著性(P<0.05);二甲双胍组治疗前后FSH、LHF、BG0 h、T无显著性差异(P>0.05),FBG1 hF、BG2 h、FI0 hF、I1 h、FI2 h治疗后均低于治疗前,差异且具有显著性(P<0.05);妈富隆与二甲双胍联合用药组治疗前后FSH、FBG0h无显著性差异(P>0.05),FBG1 h、FBG2 h、FI0 hF、I1 h、FI2 h、T、LH治疗后均低于治疗前,且差异具有显著性(P<0.05)。结论妈富隆联合二甲双胍治疗PCOS较单用妈富隆或二甲双胍效果好,是目前治疗PCOS的理想方法。更多还原

【Abstract】 Objective To study the effect of combined marvelon and metformin in treatment of polycystic ovarian syndrome(PCOS). Methods Ninety-three patients with PCOS were randomized to receive marvelon alone,metformin alone or combined marvelon and metformin respectively.Each group contained 31 patients.Follicle-stimulating hormone(FSH),luteinizing hormone (LH),testosterone(T),fasting blood glucose(FBG),fasting insulin(FI) were compared before and after a 12-week period therapy. Results After a 12-week period therapy,in the marvelone group,FSH, FBG 0h,FBG 1h,FBG 2h,FI 0h,FI 1h and FI 2h had no significant change(P>0.05),LH and T decreased significantly(P<0.05);in the metformin group,FSH,LH,FBG 0h and T had no significant change(P>0.05),but FBG 1h,FBG 2h,FI 0h,FI 1h and FI 2h decreased significantly(P<0.05);in the combined group,FSH and FBG 0h had no significant change(P>0.05),but FBG 1h,FBG 2h,FI 0h,FI 1h,FI 2h,T and LH decreased significantly(P<0.05). Conclusion Combined marvelon and metformin therapy is more effective than marvelon or metformin alone in treatment of PCOS,and this is the ideal treatment of PCOS by nowadays.更多还原