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延缓失神经肌萎缩提高功能恢复的实验研究

The Experiment Study of Depressing the Atrophy of Muscle Lost Nerve Control and Promoting Their Function

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【作者】 杨晓霞孙佩杰李娜然韩丽华潘晓蔚

【Author】 YANG Xiao-xia,SUN Pei-jie,LI Na-ran,HAN Li-hua,PAN Xiao-wei(Department of Pathology,Shenyang Medical College,Shenyang 110034,China)

【机构】 沈阳医学院医学基础部病理解剖学教研室沈阳医学院医学基础部病理解剖学教研室 辽宁沈阳110034辽宁沈阳110034

【摘要】 目的:减轻结缔组织增生的干扰,促进神经胶质细胞增生和轴突再生,提高脊髓神经纤维的再生效果,延缓肌萎缩提高功能恢复。方法:切除狗L1-2L3-4脊髓节段,采用缝匠肌尾侧部桥接脊髓缺损局部,术后不同时间采用行为学和形态学方法进行测试和观察。结果:肌桥段内有再生的神经纤维,肌萎缩逐渐恢复,双下肢运动功能有所恢复,Tarlov Motor Scotol分级2~4级。结论:肌桥桥接脊髓缺损局部减轻结缔组织增生的干扰,提高脊髓神经纤维的再生效果,延缓肌萎缩提高功能恢复。

【Abstract】 Objective: To depress the effects of hyperplasia of connective tisses,accelerating proliferation of glial cells and axonal regeneration and promoting the regeneration effects of spinal nerve fiber and depressing the lost nerve control muscles atrophy,and promoting the recovery of their function.Methods: Spinal segements L12 and L3-4 of the dogs were cut.The sartorius were sutured to the local spinal defect.The spinal defect was observed by praxiological and morphological methods at different postoperative time.Results: There were some regenerative neve fibers in bridged muscle.The atrophy muscles recovered gradually.The motor functions of the both lower extremities gradually recovered and were graded to 24 by Tarlov Motor Scotol grading.Conclusion: Depressing the effects of hyperplasia of connective tisses in the local spinal defect,and promoting the effects of nerve regeneration,and depressing the lost nerve control muscles atrophy,and promoting the recover of their function.

【关键词】 神经再生肌萎缩功能恢复
【Key words】 nerve regenerationmuscle atrophyfunction recover
【基金】 辽宁省自然基金资助项目(2001420-0101)
  • 【文献出处】 沈阳医学院学报 ,Journal of Shenyang Medical College , 编辑部邮箱 ,2006年02期
  • 【分类号】R363
  • 【下载频次】50
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