【摘要】 目的了解稳定性二氧化氯反复使用的生物安全性。方法采用多次完整皮肤刺激试验和亚急性毒性试验进行观察。结果在兔多次完整皮肤刺激试验中,稳定性二氧化氯在二氧化氯含量为1996.5mg/L的浓度下多次接触动物完整皮肤未引起动物皮肤刺激反应,属于无刺激性物质;在亚急性毒性试验中,动物经过30d喂养后,试验各剂量组实验动物生长发育良好,体重增加正常,与正常对照组相比较,差异无显著性;各剂量组实验动物血常规和血生化指标与对照组比较差异均无显著性;实验动物各脏器均未见明显病理改变。结论该稳定性二氧化氯在本次试验条件下,未显示对兔完整皮肤有刺激作用;也未显示对大鼠有亚急性毒性作用。更多还原

【Abstract】 Objective To study the toxicological safety of stable chlorine dioxide(SCD)for repeated use. Methods Both 14-day epidermis-stimulating test and 30-day feeding test were used to observe SCD subacute toxicity. Results The stable chlorine dioxide(SCD)had no the epidermis of tested rabbits in 14 days. After 30-day feeding,the experimental animals of different dosage groups developed well and their body weight increased normally. There was no significant difference compared with control group. The blood routine and blood biochemical parameters of the animals in different dosage groups showed no significant difference compared with the control group. No obvious pathological changes of various organs were seen in test animals. Conclusion The results indicate that the stable chlorine dioxide could have no effect on stimulation to the epidermis in rabbits and subacute toxicity in rats.更多还原