【摘要】 实验研究了硫辛酸(LipoicAcid,LA)对饲喂高脂日粮大鼠脂肪代谢及其抗氧化能力的影响。24只SD大鼠分成3组,分别是常规日粮对照组,高脂日粮组和高脂日粮+LA(0.1%)组。结果表明饲喂高脂日粮可导致大鼠实验性高脂血症,与高脂模型组相比,日粮中添加LA可显著降低大鼠血清TG、TC、LDL-C的含量,使动脉粥样硬化指数降低(p<0.05),显著增加血清HDL-C的含量(p<0.05),显著提高血清LPL和HL的活性;使血清和组织T-AOC、SOD活性、GSH含量显著上升(p<0.05),MDA含量显著降低(p<0.05)。说明添加LA对饲喂高脂日粮大鼠的血脂水平有明显的调节作用,可有效抑制脂质过氧化,预防动脉粥样硬化的发生。更多还原

【Abstract】 In this work the effects of Lipoic acid(LA) on blood lipid metabolism and antioxidation capability of rats fed with high-fat diet were explored. 24SD rats were divided into 3 groups: control group,high-fat group and LA (0.1%)group. Results showed that high-fat diet can cause hyperlipidemia.The content of TG, TC, LDL-C in serum were decreased significantly in LA group while the content of HDL-C in serum increased significantly.In comparison with high-fat group, both activities of LPL, HL, SOD in serum and the content of T-AOC, GSH, MDA in both serum and tissue increased significantly in LA group. Moreover, LA could decrease atherosclerotic index(AI). Conclusions: LA has the function of reducing blood lipid and anti-lipid peroxidation, and preventing from atherosclerosis.更多还原